Merck Senior Scientist, Gene Modulation in Boston, Massachusetts

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

We are seeking a scientist with demonstrated experience in functional genomics, neuroscience and cellular biology to join the Neurogenetics team within the Department of Genetics & Pharmacogenomics (GpGx) at MRL Boston. Our mission is to leverage human genetics to identify and functionally validate novel targets and pathways for therapeutic intervention and drug development in diseases such as ALS, Parkinson and Alzheimer disease.

You will serve as a hands-on experimentalist who will develop and refine models (including but not limited to iPSC neurons, primary cells, cell lines, etc.) to explore disease-relevant genes and mutations (CRISPR, RNAi, etc.) to both characterize the basic cellular pathophysiology of disease, and to determine the genetic backgrounds in which a given therapeutic strategy is most likely to be efficacious.

In this exciting role, you will:

  • Design and lead research which will address the critical questions of disease mechanism associated with genetic variants,

  • Working closely with a team of disease biologists and bioinformaticians to apply functional genomic and cellular tools to address key questions about genetic targets and disease pathways

  • Staying up to date on disease pathophysiology, especially in neurodegenerative disease, and using this information to design experiments to interrogate disease mechanisms.

  • Genetic/genomic alteration of cells (CRISPR, RNAi, etc.) and in-depth characterization of critical phenotypes of cells and cell lines.

  • Development of cell-based assays using a variety of technologies (imaging, etc.) for measuring disease-relevant phenotypes, with an eye towards high-throughput screening

Education Minimum Requirement:

  • Ph.D in Neuroscience, Genetics, Molecular Biology or similar field with a minimum of 3 years in basic research / Post – doc OR An M.D. with minimum of 5 years basic research experience

Required Experience and Skills:

  • An understanding of human genetics and the tools used to identify disease-associated genetic variation

  • Ability to design a plan of research based on genetic results to determine the cellular/pathophysiologic mechanism of given mutations in disease development

  • Robust in vitro and cell biology techniques, including primary and recombinant cell culture, molecular cloning and gene expression in human cellular systems, Western blotting, immunocytochemistry and cellular imaging.

  • Solid collaboration skills, including an ability to communicate experiment design, results and conclusions in a clear and concise manner.

  • Demonstrated written and verbal communication of study results to project teams, including proposals for further experiments to validate key findings

  • Keen attention to detail and the innate sense of urgency necessary for rapid experimental iteration

Preferred Experience and Skills:

  • Experience with genetic manipulation and cell-based assays using primary neuronal culture, iPSC-derived cell types, and cell lines

  • Experience with imaging-based platforms

  • Experience in characterizing cellular pathology, protein aggregation, organelle function

  • Disease area knowledge in neurodegeneration

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com .

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Job Biology-Discovery

Other Locations: NA-US-PA-West Point

Title: Senior Scientist, Gene Modulation

Primary Location: NA-US-MA-Boston

Requisition ID: BIO005377