Merck Jobs

Job Description

We are seeking a highly qualified and motivated Principal Scientist with a strong background in immune-oncology data science to join a cross-functional team within Discovery Oncology. The successful candidate will have a track record of innovative and collaborative research as well as experience managing other scientists. Primary responsibilities will include analysis of lab-based translational data, clinical trial biomarker datasets, development of new single cell sequencing datasets . The Principal Scientist will operate in a highly collaborative and matrixed environment, and an ability to communicate clearly and collaborate effectively with colleagues from different disciplines will be essential. This position will be located at our South San Fransisco research facility, with collaborations across colleagues in Data and Genome Sciences, the V940 INT Prograas well as Quantitative Biosciences, Discovery Biologics, Immunology, and will also work closely with Discovery Oncology colleagues in Boston and Cambridge.

Responsibilities include:

• Supervising the design, execution, interpretation, and communication of experiments to identify and validate cancer vaccine antigens and novel targets in Oncology, IO trial biomarkers and antitumor T cell biology with an ability to integrate in vitro and in vivo discovery strategies

• Supervising and conducting the development of new analytic methods to support target discovery and drug discovery efforts

• Monitoring, reviewing, and critically interpreting published work to guide internal research, particularly pertaining to high throughput data analysis

• Analysis of tumor microenvironment data, cell deconvolution and identification of data supporting combination strategies for clinical development.

• Proactively engaging with colleagues from diverse functional areas as well as developing external collaborations with academic and biotechnology partners to develop and integrate enabling technology to identify and validate novel targets

• Working as part of a cross-functional team with colleagues from Discovery Oncology, in vivo Pharmacology, Data and Genome Sciences, Chemical Biology, and Quantitative Biosciences to identify new targets and advance drug discovery efforts

• Facilitates communication and alignment with key stakeholders upstream and downstream

Education:

• Ph.D. in cell and molecular biology, cancer biology, immunology, or related discipline with nine (9) years of relevant post graduate experience

Required Experience and Skills:

• Demonstrated expertise and hands-on experience in data science and analysis of immunology, oncology and clinical trial data, particularly sequence data

• Experience managing scientists and demonstrated ability to manage multiple projects

• Demonstrated ability to work as part of a team in a matrixed organization to execute experimental plans and deliver results

• Expertise in data processing and analysis platforms across sequencing and immunology assays.

• Candidate should be a strong team player with excellent oral and written communication skills and with a demonstrated ability to work collaboratively and thrive in a team environment

• Proven record of innovative thinking to propose and champion new ideas and solve problems

Preferred Experience and Skills:

• Expertise in data derived from standard molecular biology techniques including PCR, qRT-PCR, and western blotting. Expertise in data from multiple methods of genetic perturbation (siRNA, shRNA, CRISPR using lentivirus and RNPs, inducible systems). Expertise in immunology model and assay development and data.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)

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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected salary range:

$167,700.00 - $263,900.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here (https://www.benefitsatmerck.com/) .

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Hybrid

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

No

Job Posting End Date:

08/31/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date: 08/31/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R303484